In Blow-Up, a collection of essays that tackle aesthetics from the angle of neuroscience, Warren Neidich proposes a different and wholly original paradigm for thinking through cultural history and the philosophy of the human subject. Across the theoretical landscape that Neidich describes, even familiar monuments from the history of art, architecture, philosophy and aesthetics appear strange and disorienting, because the starting point of the primary and secondary repertoires (the nervous system and the pathways of connection built up through interaction between the brain and the outside world) is so totally unexpected.